Kifaru 100mg

Kifaru has physiologic mechanism of erection of the penis which involves release of nitric oxide in the corpus cavernosum during sexual stimulation. nitric oxide then activates the enzyme guanylate cyclase, which results in increased levels of cyclic guanosine monophosphate (cgmp), producing smooth muscle relaxation in the corpus cavernosum and allowing inflow of blood. kifaru has no direct relaxant effect on isolated human corpus cavernosum, but enhances the effect of nitric oxide by inhibiting phosphodiesterase type 5 (pde5), which is responsible for degradation of cgmp in the corpus cavernosum. when sexual stimulation causes local release of nitric oxide, inhibition of pde5 by sildenafil causes increased levels of cgmp in the corpus cavernosum, resulting in smooth muscle relaxation and inflow of blood to the corpus cavernosum. sildenafil at recommended doses has no effect in the absence of sexual stimulation. studies in vitro have shown that kifaru is selective for pde5.